Pro-asthmatic cytokines regulate unliganded and ligand-dependent glucocorticoid receptor signaling in airway smooth muscle.

Pro-asthmatic cytokines regulate unliganded and ligand-dependent glucocorticoid receptor signaling in airway smooth muscle.

To elucidate the regulation of glucocorticoid receptor (GR) signaling under pro-asthmatic conditions, cultured human airway smooth muscle (HASM) cells were treated with proinflammatory cytokines or GR ligands alone and in combination, and then examined for induced changes in ligand-dependent and -in...

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Bibliographic Details
Main Authors: Aihua Hu, Maureen B Josephson, Barry L Diener, Gustavo Nino, Shuyun Xu, Chinmay Paranjape, Jordan S Orange, Michael M Grunstein
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3617099?pdf=render

Internet

http://europepmc.org/articles/PMC3617099?pdf=render

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