In Vitro Neuroprotective and Anti-Inflammatory Activities of Natural and Semi-Synthetic Spirosteroid Analogues

In Vitro Neuroprotective and Anti-Inflammatory Activities of Natural and Semi-Synthetic Spirosteroid Analogues

Two spirosteroid analogues were synthesized and evaluated for their in vitro neuroprotective activities in PC12 cells, against glutamate-induced excitotoxicity and mitochondrial damage in glucose deprivation conditions, as well as their anti-inflammatory potential in LPS/IFNγ-stimulated microglia pr...

Full description

Bibliographic Details
Main Authors: Laura García-Pupo, Armando Zaldo-Castro, Vassiliki Exarchou, Juan Enrique Tacoronte-Morales, Luc Pieters, Wim Vanden Berghe, Yanier Nuñez-Figueredo, René Delgado-Hernández
Format: Article
Language:English
Published: MDPI AG 2016-07-01
Series:Molecules
Subjects:
spirosteroids
excitotoxicity
neuroprotection
inflammatory mediators
Online Access:http://www.mdpi.com/1420-3049/21/8/992

Internet

http://www.mdpi.com/1420-3049/21/8/992

Similar Items