Caffeine prevents oxalate-induced epithelial-mesenchymal transition of renal tubular cells by its anti-oxidative property through activation of Nrf2 signaling and suppression of Snail1 transcription factor

Caffeine prevents oxalate-induced epithelial-mesenchymal transition of renal tubular cells by its anti-oxidative property through activation of Nrf2 signaling and suppression of Snail1 transcription factor

Caffeine is an active ingredient found in coffee and energy beverages. Its hepatoprotective effects against liver fibrosis are well-documented. Nonetheless, its renoprotective effects against renal fibrogenesis and epithelial-mesenchymal transition (EMT) processes remain unclear and under-investigat...

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Bibliographic Details
Main Authors: Rattiyaporn Kanlaya, Chonnicha Subkod, Supanan Nanthawuttiphan, Visith Thongboonkerd
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Coffee
CKD
EMT
Hyperoxaluria
Oxidized proteins
Renal fibrosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332221006521

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http://www.sciencedirect.com/science/article/pii/S0753332221006521

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