Lentiviral Vector Purification Using Genetically Encoded Biotin Mimic in Packaging Cell

Lentiviral vectors (LVs) have recently witnessed an increasing demand in research and clinical applications. Their current purification processes represent the main bottleneck in their widespread use, as the methods used are cumbersome and yield low recoveries. We aimed to develop a one-step method...

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Bibliographic Details
Main Authors: Leila Mekkaoui, Farhaan Parekh, Ekaterini Kotsopoulou, David Darling, Glenda Dickson, Gordon W. Cheung, Lucas Chan, Kirsty MacLellan-Gibson, Giada Mattiuzzo, Farzin Farzaneh, Yasuhiro. Takeuchi, Martin Pule
Format: Article
Language:English
Published: Elsevier 2018-12-01
Series:Molecular Therapy: Methods & Clinical Development
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050118301049