Rett syndrome linked to defects in forming the MeCP2/Rbfox/LASR complex in mouse models

Rett syndrome linked to defects in forming the MeCP2/Rbfox/LASR complex in mouse models

MeCP2 mutations can cause Rett syndrome, a severe childhood neurological disorder. Here the authors show that MeCP2 mediates the higher-order assembly of a large splicing complex Rbfox/LASR, which is disrupted in the mouse models of Rett syndrome.

Bibliographic Details
Main Authors: Yan Jiang, Xing Fu, Yuhan Zhang, Shen-Fei Wang, Hong Zhu, Wei-Kang Wang, Lin Zhang, Ping Wu, Catherine C. L. Wong, Jinsong Li, Jinbiao Ma, Ji-Song Guan, Ying Huang, Jingyi Hui
Format: Article
Language:English
Published: Nature Publishing Group 2021-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-26084-3

Internet

https://doi.org/10.1038/s41467-021-26084-3

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