20S-Hydroxyvitamin D3, a Secosteroid Produced in Humans, Is Anti-Inflammatory and Inhibits Murine Autoimmune Arthritis

20S-Hydroxyvitamin D3, a Secosteroid Produced in Humans, Is Anti-Inflammatory and Inhibits Murine Autoimmune Arthritis

The ability to use large doses of vitamin D3 (D3) to chronically treat autoimmune diseases such as rheumatoid arthritis (RA) is prohibitive due to its calcemic effect which can damage vital organs. Cytochrome P450scc (CYP11A1) is able to convert D3 into the noncalcemic analog 20S-hydroxyvitamin D3 [...

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Bibliographic Details
Main Authors: Arnold E. Postlethwaite, Robert C. Tuckey, Tae-Kang Kim, Wei Li, Syamal K. Bhattacharya, Linda K. Myers, David D. Brand, Andrzej T. Slominski
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
vitamin D
arthritis
RA
20S(OH)D3
mouse
collagen
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.678487/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.678487/full

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