Helminth Immunomodulation in Autoimmune Disease

Helminths have evolved to become experts at subverting immune surveillance. Through potent and persistent immune tempering, helminths can remain undetected in human tissues for decades. Redirecting the immunomodulating “talents” of helminths to treat inflammatory human diseases is receiving intensiv...

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Main Authors:	John J. Miles, Taylor B. Smallwood, Paul R. Giacomin, Alex Loukas, Jason P. Mulvenna, Richard J. Clark
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2017-04-01
Series:	Frontiers in Immunology
Subjects:	helminthic therapy autoimmunity immunomodulation excretory/secretory products immunotherapy
Online Access:	http://journal.frontiersin.org/article/10.3389/fimmu.2017.00453/full

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spelling	doaj-fa194f0b404b4905a77e45be34f1de1d2020-11-24T22:28:52ZengFrontiers Media S.A.Frontiers in Immunology1664-32242017-04-01810.3389/fimmu.2017.00453257359Helminth Immunomodulation in Autoimmune DiseaseJohn J. Miles0John J. Miles1John J. Miles2John J. Miles3Taylor B. Smallwood4Paul R. Giacomin5Alex Loukas6Jason P. Mulvenna7Jason P. Mulvenna8Jason P. Mulvenna9Richard J. Clark10Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD, AustraliaQIMR Berghofer Medical Research Institute, Brisbane, QLD, AustraliaDivision of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UKSchool of Medicine, The University of Queensland, Brisbane, QLD, AustraliaSchool of Biomedical Sciences, The University of Queensland, Brisbane, QLD, AustraliaCentre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD, AustraliaCentre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD, AustraliaSchool of Biomedical Sciences, The University of Queensland, Brisbane, QLD, AustraliaCentre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD, AustraliaQIMR Berghofer Medical Research Institute, Brisbane, QLD, AustraliaSchool of Biomedical Sciences, The University of Queensland, Brisbane, QLD, AustraliaHelminths have evolved to become experts at subverting immune surveillance. Through potent and persistent immune tempering, helminths can remain undetected in human tissues for decades. Redirecting the immunomodulating “talents” of helminths to treat inflammatory human diseases is receiving intensive interest. Here, we review therapies using live parasitic worms, worm secretions, and worm-derived synthetic molecules to treat autoimmune disease. We review helminth therapy in both mouse models and clinical trials and discuss what is known on mechanisms of action. We also highlight current progress in characterizing promising new immunomodulatory molecules found in excretory/secretory products of helminths and their potential use as immunotherapies for acute and chronic inflammatory diseases.http://journal.frontiersin.org/article/10.3389/fimmu.2017.00453/fullhelminthic therapyautoimmunityimmunomodulationexcretory/secretory productsimmunotherapy
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	John J. Miles John J. Miles John J. Miles John J. Miles Taylor B. Smallwood Paul R. Giacomin Alex Loukas Jason P. Mulvenna Jason P. Mulvenna Jason P. Mulvenna Richard J. Clark
spellingShingle	John J. Miles John J. Miles John J. Miles John J. Miles Taylor B. Smallwood Paul R. Giacomin Alex Loukas Jason P. Mulvenna Jason P. Mulvenna Jason P. Mulvenna Richard J. Clark Helminth Immunomodulation in Autoimmune Disease Frontiers in Immunology helminthic therapy autoimmunity immunomodulation excretory/secretory products immunotherapy
author_facet	John J. Miles John J. Miles John J. Miles John J. Miles Taylor B. Smallwood Paul R. Giacomin Alex Loukas Jason P. Mulvenna Jason P. Mulvenna Jason P. Mulvenna Richard J. Clark
author_sort	John J. Miles
title	Helminth Immunomodulation in Autoimmune Disease
title_short	Helminth Immunomodulation in Autoimmune Disease
title_full	Helminth Immunomodulation in Autoimmune Disease
title_fullStr	Helminth Immunomodulation in Autoimmune Disease
title_full_unstemmed	Helminth Immunomodulation in Autoimmune Disease
title_sort	helminth immunomodulation in autoimmune disease
publisher	Frontiers Media S.A.
series	Frontiers in Immunology
issn	1664-3224
publishDate	2017-04-01
description	Helminths have evolved to become experts at subverting immune surveillance. Through potent and persistent immune tempering, helminths can remain undetected in human tissues for decades. Redirecting the immunomodulating “talents” of helminths to treat inflammatory human diseases is receiving intensive interest. Here, we review therapies using live parasitic worms, worm secretions, and worm-derived synthetic molecules to treat autoimmune disease. We review helminth therapy in both mouse models and clinical trials and discuss what is known on mechanisms of action. We also highlight current progress in characterizing promising new immunomodulatory molecules found in excretory/secretory products of helminths and their potential use as immunotherapies for acute and chronic inflammatory diseases.
topic	helminthic therapy autoimmunity immunomodulation excretory/secretory products immunotherapy
url	http://journal.frontiersin.org/article/10.3389/fimmu.2017.00453/full
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Helminth Immunomodulation in Autoimmune Disease

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