Early-life adversity facilitates acquisition of cocaine self-administration and induces persistent anhedonia

Early-life adversity increases the risk for emotional disorders such as depression and schizophrenia. Anhedonia, thought to be a core feature of these disorders, is provoked by our naturalistic rodent model of childhood adversity (i.e., rearing pups for one week in cages with limited bedding and nes...

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Bibliographic Details
Main Authors: Jessica L. Bolton, Christina M. Ruiz, Neggy Rismanchi, Gissell A. Sanchez, Erik Castillo, Jeff Huang, Christopher Cross, Tallie Z. Baram, Stephen V. Mahler
Format: Article
Language:English
Published: Elsevier 2018-02-01
Series:Neurobiology of Stress
Online Access:http://www.sciencedirect.com/science/article/pii/S2352289517300401