The Bile Salt Export Pump: Molecular Structure, Study Models and Small-Molecule Drugs for the Treatment of Inherited BSEP Deficiencies

The Bile Salt Export Pump: Molecular Structure, Study Models and Small-Molecule Drugs for the Treatment of Inherited BSEP Deficiencies

The bile salt export pump (BSEP/ABCB11) is responsible for the transport of bile salts from hepatocytes into bile canaliculi. Malfunction of this transporter results in progressive familial intrahepatic cholestasis type 2 (PFIC2), benign recurrent intrahepatic cholestasis type 2 (BRIC2) and intrahep...

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Bibliographic Details
Main Authors: Muhammad Imran Sohail, Yaprak Dönmez-Cakil, Dániel Szöllősi, Thomas Stockner, Peter Chiba
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
BSEP
ABCB11
bile salts
intrahepatic cholestasis
chaperones
PFIC2
Online Access:https://www.mdpi.com/1422-0067/22/2/784

Internet

https://www.mdpi.com/1422-0067/22/2/784

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