Cholesterol Retards Senescence in Bone Marrow Mesenchymal Stem Cells by Modulating Autophagy and ROS/p53/p21Cip1/Waf1 Pathway

Cholesterol Retards Senescence in Bone Marrow Mesenchymal Stem Cells by Modulating Autophagy and ROS/p53/p21Cip1/Waf1 Pathway

In the present study, we demonstrated that bone marrow mesenchymal stem cells (BMSCs) of the 3rd passage displayed the senescence-associated phenotypes characterized with increased activity of SA-β-gal, altered autophagy, and increased G1 cell cycle arrest, ROS production, and expression of p53 and...

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Bibliographic Details
Main Authors: Mingyu Zhang, Yue Du, Renzhong Lu, You Shu, Wei Zhao, Zhuoyun Li, Yu Zhang, Ruixue Liu, Ti Yang, Shenjian Luo, Ming Gao, Yue Zhang, Guiye Zhang, Jiaqi Liu, Yanjie Lu
Format: Article
Language:English
Published: Hindawi Limited 2016-01-01
Series:Oxidative Medicine and Cellular Longevity
Online Access:http://dx.doi.org/10.1155/2016/7524308

Internet

http://dx.doi.org/10.1155/2016/7524308

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