On the singular, dual, and multiple positional specificity of manganese lipoxygenase and its G316A mutant

On the singular, dual, and multiple positional specificity of manganese lipoxygenase and its G316A mutant

Abstract manganese lipoxygenase (Mn-LO) oxygenates 18:3n-3 and 18:2n-6 to bis-allylic 11S-hydroperoxy fatty acids, which are converted to 13R-hydroperoxy fatty acids. Other unsaturated C16-C22 fatty acids, except 17:3n-3, are poor substrates, possibly because of ineffective enzyme activation (MnII→M...

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Bibliographic Details
Main Authors: Mirela Cristea, Ernst H. Oliw
Format: Article
Language:English
Published: Elsevier 2007-04-01
Series:Journal of Lipid Research
Subjects:
nonconjugated peroxyls
fatty acid oxygenation
hydroperoxide isomerase
mass spectrometry
metalloenzymes
dilinoleoyl-glycerophosphatidylcholine
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752043442X

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http://www.sciencedirect.com/science/article/pii/S002222752043442X

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