On the singular, dual, and multiple positional specificity of manganese lipoxygenase and its G316A mutant
Abstract manganese lipoxygenase (Mn-LO) oxygenates 18:3n-3 and 18:2n-6 to bis-allylic 11S-hydroperoxy fatty acids, which are converted to 13R-hydroperoxy fatty acids. Other unsaturated C16-C22 fatty acids, except 17:3n-3, are poor substrates, possibly because of ineffective enzyme activation (MnII→M...
Main Authors: | , |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2007-04-01
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Series: | Journal of Lipid Research |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S002222752043442X |