Conditional Deletion of PDK1 in the Forebrain Causes Neuron Loss and Increased Apoptosis during Cortical Development

Conditional Deletion of PDK1 in the Forebrain Causes Neuron Loss and Increased Apoptosis during Cortical Development

Decreased expression but increased activity of PDK1 has been observed in neurodegenerative disease. To study in vivo function of PDK1 in neuron survival during cortical development, we generate forebrain-specific PDK1 conditional knockout (cKO) mice. We demonstrate that PDK1 cKO mice display strikin...

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Bibliographic Details
Main Authors: Congyu Xu, Linjie Yu, Jinxing Hou, Rosemary J. Jackson, He Wang, Chaoli Huang, Tingting Liu, Qihui Wang, Xiaochuan Zou, Richard G. Morris, Tara L. Spires-Jones, Zhongzhou Yang, Zhenyu Yin, Yun Xu, Guiquan Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
PDK1
Akt
mTOR
neuron loss
apoptosis
learning and memory
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2017.00330/full

Internet

http://journal.frontiersin.org/article/10.3389/fncel.2017.00330/full

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