The Effect of Metformin and GANT61 Combinations on the Radiosensitivity of Prostate Cancer Cells

The anti-diabetes drug metformin has been shown to have anti-neoplastic effects in several tumor models through its effects on energy metabolism and protein synthesis. Recent studies show that metformin also targets Hedgehog (Hh) signaling, a developmental pathway re-activated in several tumor types...

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Bibliographic Details
Main Authors: Annelies Gonnissen, Sofie Isebaert, Chad M. McKee, Ruth J. Muschel, Karin Haustermans
Format: Article
Language:English
Published: MDPI AG 2017-02-01
Series:International Journal of Molecular Sciences
Subjects:
Online Access:http://www.mdpi.com/1422-0067/18/2/399