Protection of rhesus monkeys by a DNA prime/poxvirus boost malaria vaccine depends on optimal DNA priming and inclusion of blood stage antigens.

Protection of rhesus monkeys by a DNA prime/poxvirus boost malaria vaccine depends on optimal DNA priming and inclusion of blood stage antigens.

BACKGROUND: We have previously described a four antigen malaria vaccine consisting of DNA plasmids boosted by recombinant poxviruses which protects a high percentage of rhesus monkeys against Plasmodium knowlesi (Pk) malaria. This is a multi-stage vaccine that includes two pre-erythrocytic antigens,...

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Bibliographic Details
Main Authors: Walter R Weiss, Anita Kumar, George Jiang, Jackie Williams, Anthony Bostick, Solomon Conteh, David Fryauff, Joao Aguiar, Manmohan Singh, Derek T O'Hagan, Jeffery B Ulmer, Thomas L Richie
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2031826?pdf=render

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http://europepmc.org/articles/PMC2031826?pdf=render

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