Protein Quality Control Activation and Microtubule Remodeling in Hypertrophic Cardiomyopathy

Protein Quality Control Activation and Microtubule Remodeling in Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac disorder. It is mainly caused by mutations in genes encoding sarcomere proteins. Mutant forms of these highly abundant proteins likely stress the protein quality control (PQC) system of cardiomyocytes. The PQC system, together wi...

Full description

Bibliographic Details
Main Authors: Larissa M. Dorsch, Maike Schuldt, Cristobal G. dos Remedios, Arend F. L. Schinkel, Peter L. de Jong, Michelle Michels, Diederik W. D. Kuster, Bianca J. J. M. Brundel, Jolanda van der Velden
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Cells
Subjects:
cardiomyopathy
hypertrophy
sarcomere mutation
haploinsufficiency
poison polypeptide
protein quality control
heat shock proteins
autophagy
microtubules
Online Access:https://www.mdpi.com/2073-4409/8/7/741

Internet

https://www.mdpi.com/2073-4409/8/7/741

Similar Items