BRD4 and Cancer: going beyond transcriptional regulation

BRD4 and Cancer: going beyond transcriptional regulation

Abstract BRD4, member of the Bromodomain and Extraterminal (BET) protein family, is largely acknowledged in cancer for its role in super-enhancers (SEs) organization and oncogenes expression regulation. Inhibition of BRD4 shortcuts the communication between SEs and target promoters with a subsequent...

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Bibliographic Details
Main Authors: Benedetta Donati, Eugenia Lorenzini, Alessia Ciarrocchi
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Molecular Cancer
Subjects:
BRD4
BET inhibitors
Transcriptional regulation
DNA damage response
Telomere regulation
Unconventional function
Online Access:http://link.springer.com/article/10.1186/s12943-018-0915-9

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http://link.springer.com/article/10.1186/s12943-018-0915-9

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