Specificity of the STAT4 genetic association for severe disease manifestations of systemic lupus erythematosus.

Specificity of the STAT4 genetic association for severe disease manifestations of systemic lupus erythematosus.

Systemic lupus erythematosus (SLE) is a genetically complex disease with heterogeneous clinical manifestations. A polymorphism in the STAT4 gene has recently been established as a risk factor for SLE, but the relationship with specific SLE subphenotypes has not been studied. We studied 137 SNPs in t...

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Bibliographic Details
Main Authors: Kimberly E Taylor, Elaine F Remmers, Annette T Lee, Ward A Ortmann, Robert M Plenge, Chao Tian, Sharon A Chung, Joanne Nititham, Geoffrey Hom, Amy H Kao, F Yesim Demirci, M Ilyas Kamboh, Michelle Petri, Susan Manzi, Daniel L Kastner, Michael F Seldin, Peter K Gregersen, Timothy W Behrens, Lindsey A Criswell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-05-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2377340?pdf=render

Internet

http://europepmc.org/articles/PMC2377340?pdf=render

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