Therapeutic efficacy of combined vaccination against tumor pericyte-associated antigens DLK1 and DLK2 in mice

Therapeutic efficacy of combined vaccination against tumor pericyte-associated antigens DLK1 and DLK2 in mice

When compared with vascular cells in normal tissues, pericytes and vascular endothelial cells (VEC) in tumor blood vessels exhibit altered morphology and epigenetic programming that leads to the expression of unique antigens that allow for differential recognition by CD8+ T cells. We have previously...

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Bibliographic Details
Main Authors: Kellsye Paula L. Fabian, Nina Chi-Sabins, Jennifer L. Taylor, Ronald Fecek, Aliyah Weinstein, Walter J. Storkus
Format: Article
Language:English
Published: Taylor & Francis Group 2017-03-01
Series:OncoImmunology
Subjects:
cd8+ t cells
dc
immunotherapy
pericyte
tumor
vaccine
vascular endothelial cell
vascular normalization
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1290035

Internet

http://dx.doi.org/10.1080/2162402X.2017.1290035

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