Molecular biology of Philadelphia-negative myeloproliferative neoplasms

Molecular biology of Philadelphia-negative myeloproliferative neoplasms

Myeloproliferative neoplasms are clonal diseases of hematopoietic stem cells characterized by myeloid hyperplasia and increased risk of developing acute myeloid leukemia. Myeloproliferative neoplasms are caused, as any other malignancy, by genetic defects that culminate in the neoplastic phenotype....

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Bibliographic Details
Main Authors: Paulo Vidal Campregher, Fábio Pires de Souza Santos, Guilherme Fleury Perini, Nelson Hamerschlak
Format: Article
Language:English
Published: Elsevier 2012-01-01
Series:Revista Brasileira de Hematologia e Hemoterapia
Subjects:
polycythemia vera
primary myelofibrosis
thrombocythemia, essential
leukemia, myeloid, acute
myeloproliferative disorders
janus kinase 2
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842012000200015

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842012000200015

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