Transport of lipophilic carboxylates is mediated by transmembrane helix 2 in multidrug transporter AcrB

The AcrB module of the AcrAB-TolC multidrug efflux pump sequesters drugs from the periplasm and outer leaflet of the inner membrane. Here, Oswaldet al. provide evidence that lipophilic carboxylated substrates bind to a groove between transmembrane helices TM1 and TM2, for further transport by an upw...

Full description

Bibliographic Details
Main Authors: Christine Oswald, Heng-Keat Tam, Klaas M. Pos
Format: Article
Language:English
Published: Nature Publishing Group 2016-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms13819