Transport of lipophilic carboxylates is mediated by transmembrane helix 2 in multidrug transporter AcrB
The AcrB module of the AcrAB-TolC multidrug efflux pump sequesters drugs from the periplasm and outer leaflet of the inner membrane. Here, Oswaldet al. provide evidence that lipophilic carboxylated substrates bind to a groove between transmembrane helices TM1 and TM2, for further transport by an upw...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2016-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms13819 |