Repetitive Neonatal Erythropoietin and Melatonin Combinatorial Treatment Provides Sustained Repair of Functional Deficits in a Rat Model of Cerebral Palsy

Repetitive Neonatal Erythropoietin and Melatonin Combinatorial Treatment Provides Sustained Repair of Functional Deficits in a Rat Model of Cerebral Palsy

Cerebral palsy (CP) is the leading cause of motor impairment for children worldwide and results from perinatal brain injury (PBI). To test novel therapeutics to mitigate deficits from PBI, we developed a rat model of extreme preterm birth (<28 weeks of gestation) that mimics dual intrauterine...

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Bibliographic Details
Main Authors: Lauren L. Jantzie, Akosua Y. Oppong, Fatu S. Conteh, Tracylyn R. Yellowhair, Joshua Kim, Gabrielle Fink, Adam R. Wolin, Frances J. Northington, Shenandoah Robinson
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Neurology
Subjects:
cerebral palsy
chorioamnionitis
hypoxia-ischemia
inflammation
social interaction
gait
Online Access:http://journal.frontiersin.org/article/10.3389/fneur.2018.00233/full

Internet

http://journal.frontiersin.org/article/10.3389/fneur.2018.00233/full

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