Ectopic Overexpression of Sonic Hedgehog (Shh) Induces Stromal Expansion and Metaplasia in the Adult Murine Pancreas

Ectopic Overexpression of Sonic Hedgehog (Shh) Induces Stromal Expansion and Metaplasia in the Adult Murine Pancreas

Ligand-dependent activation of the Hedgehog (Hh) signaling pathway has been implicated in both tumor initiation and metastasis of pancreatic ductal adenocarcinoma (PDAC). Prior studies in genetically engineered mouse models (GEMMs) have assessed the role of Hh signaling by cell autonomous expressio...

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Bibliographic Details
Main Authors: Volker Fendrich, Edwin Oh, Seungmin Bang, Collins Karikari, Niki Ottenhof, Savita Bisht, Matthias Lauth, Peter Brossart, Nicholas Katsanis, Anirban Maitra, Georg Feldmann
Format: Article
Language:English
Published: Elsevier 2011-10-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558611800801

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http://www.sciencedirect.com/science/article/pii/S1476558611800801

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