Validation of NEDD8-conjugating enzyme UBC12 as a new therapeutic target in lung cancerResearch in context

Validation of NEDD8-conjugating enzyme UBC12 as a new therapeutic target in lung cancerResearch in context

Background: The neddylation pathway is overactivated in human cancers. Inhibition of neddylation pathway has emerged as an attractive anticancer strategy. The mechanisms underlying neddylation overactivation in cancer remain elusive. MLN4924/Pevonedistat, a first-in-class NEDD8-activating enzyme (NA...

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Main Authors: Lihui Li, Jihui Kang, Wenjuan Zhang, Lili Cai, Shiwen Wang, Yupei Liang, Yanyu Jiang, Xiaojun Liu, Yunjing Zhang, Hongfeng Ruan, Guoan Chen, Mingsong Wang, Lijun Jia
Format: Article
Language:English
Published: Elsevier 2019-07-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396419303809

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http://www.sciencedirect.com/science/article/pii/S2352396419303809

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