Specific interaction of Gαi3 with the Oa1 G-protein coupled receptor controls the size and density of melanosomes in retinal pigment epithelium.

Specific interaction of Gαi3 with the Oa1 G-protein coupled receptor controls the size and density of melanosomes in retinal pigment epithelium.

Ocular albinism type 1, an X-linked disease characterized by the presence of enlarged melanosomes in the retinal pigment epithelium (RPE) and abnormal crossing of axons at the optic chiasm, is caused by mutations in the OA1 gene. The protein product of this gene is a G-protein-coupled receptor (GPCR...

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Bibliographic Details
Main Authors: Alejandra Young, Meisheng Jiang, Ying Wang, Novruz B Ahmedli, John Ramirez, Benjamin E Reese, Lutz Birnbaumer, Debora B Farber
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3169599?pdf=render

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http://europepmc.org/articles/PMC3169599?pdf=render

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