Rapid identification of a Mycobacterium tuberculosis full genetic drug resistance profile through whole genome sequencing directly from sputum

Rapid identification of a Mycobacterium tuberculosis full genetic drug resistance profile through whole genome sequencing directly from sputum

Introduction: Resistance to second-line tuberculosis drugs is common, but slow to diagnose with phenotypic drug sensitivity testing. Rapid molecular tests speed up diagnosis, but can only detect limited mutations. Whole genome sequencing (WGS) of culture isolates can generate a complete genetic drug...

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Bibliographic Details
Main Authors: Camus Nimmo, Ronan Doyle, Carrie Burgess, Rachel Williams, Rebecca Gorton, Timothy D. McHugh, Mike Brown, Stephen Morris-Jones, Helen Booth, Judith Breuer
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:International Journal of Infectious Diseases
Subjects:
Tuberculosis
Whole genome sequencing
Drug resistance
Clinical samples
Directly from sputum
Online Access:http://www.sciencedirect.com/science/article/pii/S1201971217301856

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http://www.sciencedirect.com/science/article/pii/S1201971217301856

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