Connexin 30 deficiency attenuates A2 astrocyte responses and induces severe neurodegeneration in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Parkinson’s disease animal model

Connexin 30 deficiency attenuates A2 astrocyte responses and induces severe neurodegeneration in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Parkinson’s disease animal model

Abstract Background The first pathology observed in Parkinson’s disease (PD) is ‘dying back’ of striatal dopaminergic (DA) terminals. Connexin (Cx)30, an astrocytic gap junction protein, is upregulated in the striatum in PD, but its roles in neurodegeneration remain elusive. We investigated Cx30 fun...

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Bibliographic Details
Main Authors: Atsushi Fujita, Hiroo Yamaguchi, Ryo Yamasaki, Yiwen Cui, Yuta Matsuoka, Ken-ichi Yamada, Jun-ichi Kira
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Journal of Neuroinflammation
Subjects:
Parkinson’s disease
Dopaminergic neuron
Astrocyte
Connexin 30
MPTP
Online Access:http://link.springer.com/article/10.1186/s12974-018-1251-0

Internet

http://link.springer.com/article/10.1186/s12974-018-1251-0

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