Red Grape Skin Polyphenols Blunt Matrix Metalloproteinase-2 and -9 Activity and Expression in Cell Models of Vascular Inflammation: Protective Role in Degenerative and Inflammatory Diseases

Red Grape Skin Polyphenols Blunt Matrix Metalloproteinase-2 and -9 Activity and Expression in Cell Models of Vascular Inflammation: Protective Role in Degenerative and Inflammatory Diseases

Matrix metalloproteinases (MMPs) are endopeptidases responsible for the hydrolysis of various components of extracellular matrix. MMPs, namely gelatinases MMP-2 and MMP-9, contribute to the progression of chronic and degenerative diseases. Since gelatinases’ activity and expression are regulated by...

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Bibliographic Details
Main Authors: Nadia Calabriso, Marika Massaro, Egeria Scoditti, Mariangela Pellegrino, Ilaria Ingrosso, Giovanna Giovinazzo, Maria Annunziata Carluccio
Format: Article
Language:English
Published: MDPI AG 2016-08-01
Series:Molecules
Subjects:
antioxidants
gelatinases
endothelium
monocytes
grape skin polyphenolic extracts
gene expression
inflammation
stilbenes
flavonols
phenolic acids
Online Access:http://www.mdpi.com/1420-3049/21/9/1147

Internet

http://www.mdpi.com/1420-3049/21/9/1147

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