Quantitative and structural analysis of isotopically labelled natural crosslinks in type I skin collagen using LC-HRMS and SANS

Quantitative and structural analysis of isotopically labelled natural crosslinks in type I skin collagen using LC-HRMS and SANS

Abstract Collagen structure in biological tissues imparts its intrinsic physical properties by the formation of several covalent crosslinks. For the first time, two major crosslinks in the skin dihydroxylysinonorleucine (HLNL) and histidinohydroxymerodesmosine (HHMD), were isotopically labelled and...

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Bibliographic Details
Main Authors: Yi Zhang, Rafea Naffa, Christopher J. Garvey, Catherine A. Maidment, Sujay Prabakar
Format: Article
Language:English
Published: SpringerOpen 2019-10-01
Series:Journal of Leather Science and Engineering
Subjects:
Crosslinks
Isotopic labelling
LC-HRMS
Quantitative analysis
SANS
Collagen structure
Online Access:http://link.springer.com/article/10.1186/s42825-019-0012-x

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http://link.springer.com/article/10.1186/s42825-019-0012-x

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