Triple Function of Synaptotagmin 7 Ensures Efficiency of High-Frequency Transmission at Central GABAergic Synapses

Triple Function of Synaptotagmin 7 Ensures Efficiency of High-Frequency Transmission at Central GABAergic Synapses

Synaptotagmin 7 (Syt7) is thought to be a Ca2+ sensor that mediates asynchronous transmitter release and facilitation at synapses. However, Syt7 is strongly expressed in fast-spiking, parvalbumin-expressing GABAergic interneurons, and the output synapses of these neurons produce only minimal asynchr...

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Bibliographic Details
Main Authors: Chong Chen, Rachel Satterfield, Samuel M. Young, Jr., Peter Jonas
Format: Article
Language:English
Published: Elsevier 2017-11-01
Series:Cell Reports
Subjects:
cerebellum
basket cells
transmitter release
synaptotagmin
Ca2+ sensor
exocytosis
endocytosis
pool replenishment
GABAergic synapses
fast spiking
sustained release
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717316029

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http://www.sciencedirect.com/science/article/pii/S2211124717316029

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