Structure–Function and Therapeutic Potential of Spider Venom-Derived Cysteine Knot Peptides Targeting Sodium Channels

Structure–Function and Therapeutic Potential of Spider Venom-Derived Cysteine Knot Peptides Targeting Sodium Channels

Spider venom-derived cysteine knot peptides are a mega-diverse class of molecules that exhibit unique pharmacological properties to modulate key membrane protein targets. Voltage-gated sodium channels (NaV) are often targeted by these peptides to allosterically promote opening or closing of the chan...

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Bibliographic Details
Main Authors: Fernanda C. Cardoso, Richard J. Lewis
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Pharmacology
Subjects:
spider venoms
ICK peptides
voltage-gated ion channels
structure–activity relationship
novel drugs
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00366/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00366/full

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