Upregulation of P2Y2R, Active uPA, and PAI-1 Are Essential Components of Hantavirus Cardiopulmonary Syndrome

Upregulation of P2Y2R, Active uPA, and PAI-1 Are Essential Components of Hantavirus Cardiopulmonary Syndrome

Sin Nombre virus (SNV) causes hantavirus cardiopulmonary pulmonary syndrome (HCPS) with the loss of pulmonary vascular endothelial integrity, and pulmonary edema without causing cytopathic effects on the vascular endothelium. HCPS is associated primarily with a dysregulated immune response. We previ...

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Bibliographic Details
Main Authors: Virginie Bondu, Casey Bitting, Valerie L. Poland, Joshua A. Hanson, Michelle S. Harkins, Sarah Lathrop, Kurt B. Nolte, Daniel A. Lawrence, Tione Buranda
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
HCPS
PAI-1
uPA
P2Y2R
integrin activation
zymography
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2018.00169/full

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https://www.frontiersin.org/article/10.3389/fcimb.2018.00169/full

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