A Quantitative Modular Modeling Approach Reveals the Effects of Different A20 Feedback Implementations for the NF-kB Signaling Dynamics

A Quantitative Modular Modeling Approach Reveals the Effects of Different A20 Feedback Implementations for the NF-kB Signaling Dynamics

Signaling pathways involve complex molecular interactions and are controled by non-linear regulatory mechanisms. If details of regulatory mechanisms are not fully elucidated, they can be implemented by different, equally reasonable mathematical representations in computational models. The study pres...

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Bibliographic Details
Main Authors: Janina Mothes, Inbal Ipenberg, Seda Çöl Arslan, Uwe Benary, Claus Scheidereit, Jana Wolf
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Physiology
Subjects:
quantitative modeling
interlocked feedback loops
regulation
NF-κB signaling
A20
IKK regulation
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00896/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2020.00896/full

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