Metformin generates profound alterations in systemic and tumor immunity with associated antitumor effects

Background Metformin is a commonly used antidiabetic medication which has demonstrated promise as an anticancer agent alone and in combination with conventional treatment regimens. There is increasing evidence that metformin can also generate immunomodulatory effects in solid tumors and is currently...

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Bibliographic Details
Main Authors: Ratna Veeramachaneni, Wangjie Yu, Jared M Newton, Jan O Kemnade, Heath D Skinner, Andrew G Sikora, Vlad C Sandulache
Format: Article
Language:English
Published: BMJ Publishing Group 2021-07-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/9/7/e002773.full