Sex Dimorphism of Nonalcoholic Fatty Liver Disease (NAFLD) in <i>Pparg</i>-Null Mice

Sex Dimorphism of Nonalcoholic Fatty Liver Disease (NAFLD) in <i>Pparg</i>-Null Mice

Men with nonalcoholic fatty liver disease (NAFLD) are more exposed to nonalcoholic steatohepatitis (NASH) and liver fibrosis than women. However, the underlying molecular mechanisms of NALFD sex dimorphism are unclear. We combined gene expression, histological and lipidomic analyses to systematicall...

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Bibliographic Details
Main Authors: Mariano Schiffrin, Carine Winkler, Laure Quignodon, Aurélien Naldi, Martin Trötzmüller, Harald Köfeler, Hugues Henry, Paolo Parini, Béatrice Desvergne, Federica Gilardi
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
nonalcoholic fatty liver disease (NAFLD)
sex dimorphism
lipidomics
hepatic sex-biased gene expression
Online Access:https://www.mdpi.com/1422-0067/22/18/9969

Internet

https://www.mdpi.com/1422-0067/22/18/9969

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