Discovery of New DNA Topoisomerase II Inhibitors using Structure Based Virtual Screening Method

Discovery of New DNA Topoisomerase II Inhibitors using Structure Based Virtual Screening Method

DNA topoisomerases are proved therapeutic targets of anticancer and antibacterial drugs. Structures of topoisomerase–DNA and inhibitor ternary complexes have revealed the exact binding sites and mechanisms of topoisomerase poisons. There are two isoforms of Human Topoisomerase II; α and β. Both of t...

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Bibliographic Details
Main Authors: Tugba Ertan-Bolelli, Kayhan Bolelli
Format: Article
Language:English
Published: Turkish Chemical Society 2019-05-01
Series:Journal of the Turkish Chemical Society, Section A: Chemistry
Subjects:
anticancer activity
docking
topoisomerase
virtual screening
Online Access:http://dergipark.gov.tr/jotcsa/issue/42264/466457

Internet

http://dergipark.gov.tr/jotcsa/issue/42264/466457

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