Toxoplasma gondii Inhibits Mast Cell Degranulation by Suppressing Phospholipase Cγ-mediated Ca2+ Mobilization

Toxoplasma gondii Inhibits Mast Cell Degranulation by Suppressing Phospholipase Cγ-mediated Ca2+ Mobilization

Toxoplasma gondii is well known to subvert normal immune responses, however, mechanisms are incompletely understood. In particular, its capacity to alter receptor-activated Ca2+-mediated signaling processes has not been well-characterized. In initial experiments, we found evidence that T. gondii inf...

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Bibliographic Details
Main Authors: Norah L Smith, Delbert eAbi Abdallah, Barbara A Butcher, Eric eDenkers, Barbara eBaird, David eHolowka
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-07-01
Series:Frontiers in Microbiology
Subjects:
Neutrophils
FceRI
IgE
FcεRI
Syk kinase
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2013.00179/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2013.00179/full

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