Viral Activation of Heparanase Drives Pathogenesis of Herpes Simplex Virus-1

Viral Activation of Heparanase Drives Pathogenesis of Herpes Simplex Virus-1

Herpes simplex virus-1 (HSV-1) causes lifelong recurrent pathologies without a cure. How infection by HSV-1 triggers disease processes, especially in the immune-privileged avascular human cornea, remains a major unresolved puzzle. It has been speculated that a cornea-resident molecule must tip the b...

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Bibliographic Details
Main Authors: Alex M. Agelidis, Satvik R. Hadigal, Dinesh Jaishankar, Deepak Shukla
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Cell Reports
Subjects:
cornea
cytokines
heparan sulfate
heparanase
herpes simplex virus
inflammation
interferon
ophthalmology
transcription factors
wound healing
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717308550

Internet

http://www.sciencedirect.com/science/article/pii/S2211124717308550

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