Metabolic Switch in the Tumor Microenvironment Determines Immune Responses to Anti-cancer Therapy

Metabolic Switch in the Tumor Microenvironment Determines Immune Responses to Anti-cancer Therapy

Tumor-induced immune tolerance permits growth and spread of malignant cells. Cancer cells have strong influence on surrounding cells and shape the hypoxic tumor microenvironment (TME) facilitating cancer progression. A dynamic change in glucose metabolism occurring in cancer cells and its influence...

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Bibliographic Details
Main Authors: Barbara Wegiel, Marta Vuerich, Saeed Daneshmandi, Pankaj Seth
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Oncology
Subjects:
tumor microenvironment (TME)
metabolic reprogramming
immune stroma
HIF-1α
lactate
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2018.00284/full

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https://www.frontiersin.org/article/10.3389/fonc.2018.00284/full

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