Transplantation of neural precursors generated from spinal progenitor cells reduces inflammation in spinal cord injury via NF-κB pathway inhibition

Transplantation of neural precursors generated from spinal progenitor cells reduces inflammation in spinal cord injury via NF-κB pathway inhibition

Abstract Background Traumatic spinal cord injury (SCI) triggers a chain of events that is accompanied by an inflammatory reaction leading to necrotic cell death at the core of the injury site, which is restricted by astrogliosis and apoptotic cell death in the surrounding areas. Activation of nuclea...

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Bibliographic Details
Main Authors: Kristyna Karova, John V. Wainwright, Lucia Machova-Urdzikova, Rishikaysh V. Pisal, Meic Schmidt, Pavla Jendelova, Meena Jhanwar-Uniyal
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Journal of Neuroinflammation
Subjects:
NF-κB
p65
Spinal cord injury
Stem cells transplantation
Inflammation
TNF-α
Online Access:http://link.springer.com/article/10.1186/s12974-019-1394-7

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http://link.springer.com/article/10.1186/s12974-019-1394-7

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