Effects of Simvastatin on Lipid Metabolism in Wild-Type Mice and Mice with Muscle PGC-1α Overexpression

Effects of Simvastatin on Lipid Metabolism in Wild-Type Mice and Mice with Muscle PGC-1α Overexpression

Previous studies suggest that statins may disturb skeletal muscle lipid metabolism potentially causing lipotoxicity with insulin resistance. We investigated this possibility in wild-type mice (WT) and mice with skeletal muscle PGC-1α overexpression (PGC-1α OE mice). In WT mice, simvastatin had only...

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Bibliographic Details
Main Authors: Miljenko V. Panajatovic, Francois Singh, Stephan Krähenbühl, Jamal Bouitbir
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
simvastatin
PGC-1α
fatty acids
triglycerides
lipid droplets
perilipin 5
Online Access:https://www.mdpi.com/1422-0067/22/9/4950

Internet

https://www.mdpi.com/1422-0067/22/9/4950

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