The piggyBac transposon-mediated expression of SV40 T antigen efficiently immortalizes mouse embryonic fibroblasts (MEFs).

The piggyBac transposon-mediated expression of SV40 T antigen efficiently immortalizes mouse embryonic fibroblasts (MEFs).

Mouse embryonic fibroblasts (MEFs) are mesenchymal stem cell (MSC)-like multipotent progenitor cells and can undergo self-renewal and differentiate into to multiple lineages, including bone, cartilage and adipose. Primary MEFs have limited life span in culture, which thus hampers MEFs' basic re...

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Bibliographic Details
Main Authors: Ning Wang, Wenwen Zhang, Jing Cui, Hongmei Zhang, Xiang Chen, Ruidong Li, Ningning Wu, Xian Chen, Sheng Wen, Junhui Zhang, Liangjun Yin, Fang Deng, Zhan Liao, Zhonglin Zhang, Qian Zhang, Zhengjian Yan, Wei Liu, Jixing Ye, Youlin Deng, Zhongliang Wang, Min Qiao, Hue H Luu, Rex C Haydon, Lewis L Shi, Houjie Liang, Tong-Chuan He
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4028212?pdf=render

Internet

http://europepmc.org/articles/PMC4028212?pdf=render

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