When Does Choice of Accuracy Measure Alter Imputation Accuracy Assessments?

When Does Choice of Accuracy Measure Alter Imputation Accuracy Assessments?

Imputation, the process of inferring genotypes for untyped variants, is used to identify and refine genetic association findings. Inaccuracies in imputed data can distort the observed association between variants and a disease. Many statistics are used to assess accuracy; some compare imputed to gen...

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Bibliographic Details
Main Authors: Shelina Ramnarine, Juan Zhang, Li-Shiun Chen, Robert Culverhouse, Weimin Duan, Dana B Hancock, Sarah M Hartz, Eric O Johnson, Emily Olfson, Tae-Hwi Schwantes-An, Nancy L Saccone
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4601794?pdf=render

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http://europepmc.org/articles/PMC4601794?pdf=render

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