SOX21 Ensures Rostral Forebrain Identity by Suppression of WNT8B during Neural Regionalization of Human Embryonic Stem Cells

Summary: The generation of brain region-specific progenitors from human embryonic stem cells (hESCs) is critical for their application. However, transcriptional regulation of neural regionalization in humans is poorly understood. Here, we applied a rostrocaudal patterning system from hESCs to dissec...

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Bibliographic Details
Main Authors: Zhuoqing Fang, Xinyuan Liu, Jing Wen, Fan Tang, Yang Zhou, Naihe Jing, Ying Jin
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671119303741