Full restoration of specific infectivity and strain properties from pure mammalian prion protein.

The protein-only hypothesis predicts that infectious mammalian prions are composed solely of PrPSc, a misfolded conformer of the normal prion protein, PrPC. However, protein-only PrPSc preparations lack significant levels of prion infectivity, leading to the alternative hypothesis that cofactor mole...

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Bibliographic Details
Main Authors: Cassandra M Burke, Daniel J Walsh, Alexander D Steele, Umberto Agrimi, Michele Angelo Di Bari, Joel C Watts, Surachai Supattapone
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-03-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC6448948?pdf=render