Synthesis and Structure-Activity Relationships of Imidazole-Coumarin Conjugates against Hepatitis C Virus

Synthesis and Structure-Activity Relationships of Imidazole-Coumarin Conjugates against Hepatitis C Virus

A series of new conjugated compounds with a –SCH2– linkage were synthesized by chemical methods from imidazole and coumarin derivatives. The experimental results indicate that of the twenty newly synthesized imidazole–coumarin conjugates, three of them exhibited appealing EC50 values (5.1–8.4 μM) an...

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Bibliographic Details
Main Authors: Shwu-Chen Tsay, Shu-Yu Lin, Wen-Chieh Huang, Ming-Hua Hsu, Kuo Chu Hwang, Chun-Cheng Lin, Jia-Cherng Horng, I-Chia Chen, Jih Ru Hwu, Fa-Kuen Shieh, Pieter Leyssen, Johan Neyts
Format: Article
Language:English
Published: MDPI AG 2016-02-01
Series:Molecules
Subjects:
imidazole
nitrogen heterocycles
coumarin
hepatitis C virus
structure–activity relationships
Online Access:http://www.mdpi.com/1420-3049/21/2/228

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http://www.mdpi.com/1420-3049/21/2/228

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