CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function

CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function

Various kinases, including a cyclin-dependent kinase (CDK) family member, regulate the growth and functions of primary cilia, which perform essential roles in signaling and development. Neurological disorders linked to CDK-Like (CDKL) proteins suggest that these underexplored kinases may have simila...

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Bibliographic Details
Main Authors: Peter Canning, Kwangjin Park, João Gonçalves, Chunmei Li, Conor J. Howard, Timothy D. Sharpe, Liam J. Holt, Laurence Pelletier, Alex N. Bullock, Michel R. Leroux
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Cell Reports
Subjects:
cilium length
Cyclin-Dependent Kinase-Like
CDKL
kinase
neurological disorder
protein structure
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717319204

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http://www.sciencedirect.com/science/article/pii/S2211124717319204

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