Novel Epigenetic CREB-miR-630 Signaling Axis Regulates Radiosensitivity in Colorectal Cancer.

miR-630 has been reported to be a modulator of several cancers, but the mechanism by which is it influences radioresistance remains unknown. We aimed to identify the molecular function of miR-630 and its regulatory mechanism in colorectal cancer (CRC) cell lines.Overexpression and loss-of-function a...

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Bibliographic Details
Main Authors: Yan Zhang, Jiang Yu, Hao Liu, Wenhui Ma, Li Yan, Jiefu Wang, Guoxin Li
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4532457?pdf=render