Modeling Genomic Instability and Selection Pressure in a Mouse Model of Melanoma

Modeling Genomic Instability and Selection Pressure in a Mouse Model of Melanoma

Tumor evolution is an iterative process of selection for pro-oncogenic aberrations. This process can be accelerated by genomic instability, but how it interacts with different selection bottlenecks to shape the evolving genomic landscape remains understudied. Here, we assessed tumor initiation and t...

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Bibliographic Details
Main Authors: Lawrence N. Kwong, Lihua Zou, Sharmeen Chagani, Chandra Sekhar Pedamallu, Mingguang Liu, Shan Jiang, Alexei Protopopov, Jianhua Zhang, Gad Getz, Lynda Chin
Format: Article
Language:English
Published: Elsevier 2017-05-01
Series:Cell Reports
Subjects:
mouse models
genomic instability
selection pressure
tumor evolution
tumor genomics
melanoma
drug resistance
telomere dysfunction
evolution bottlenecks
copy number aberrations
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717305764

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http://www.sciencedirect.com/science/article/pii/S2211124717305764

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