Structurally designed attenuated subunit vaccines for S. aureus LukS-PV and LukF-PV confer protection in a mouse bacteremia model.

Structurally designed attenuated subunit vaccines for S. aureus LukS-PV and LukF-PV confer protection in a mouse bacteremia model.

Previous efforts towards S. aureus vaccine development have largely focused on cell surface antigens to induce opsonophagocytic killing aimed at providing sterile immunity, a concept successfully applied to other Gram-positive pathogens such as Streptococcus pneumoniae. However, these approaches hav...

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Bibliographic Details
Main Authors: Hatice Karauzum, Rajan P Adhikari, Jawad Sarwar, V Sathya Devi, Laura Abaandou, Christian Haudenschild, Mahta Mahmoudieh, Atefeh R Boroun, Hong Vu, Tam Nguyen, Kelly L Warfield, Sergey Shulenin, M Javad Aman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3676412?pdf=render

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http://europepmc.org/articles/PMC3676412?pdf=render

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