A natural genetic variant of granzyme B confers lethality to a common viral infection.

A natural genetic variant of granzyme B confers lethality to a common viral infection.

Many immune response genes are highly polymorphic, consistent with the selective pressure imposed by pathogens over evolutionary time, and the need to balance infection control with the risk of auto-immunity. Epidemiological and genomic studies have identified many genetic variants that confer susce...

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Bibliographic Details
Main Authors: Christopher E Andoniou, Vivien R Sutton, Matthew E Wikstrom, Peter Fleming, Kevin Y T Thia, Antony Y Matthews, Dion Kaiserman, Iona S Schuster, Jerome D Coudert, Preethi Eldi, Geeta Chaudhri, Gunasegaran Karupiah, Phillip I Bird, Joseph A Trapani, Mariapia A Degli-Esposti
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-12-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1004526

Internet

https://doi.org/10.1371/journal.ppat.1004526

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